Organic & Biomolecular Chemistry
Paper
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Fig. 2 Experimental procedure.
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by-product derived from homo-coupling of aryl boronic acids.
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was filtered under decompression again and washed with
20 mL distilled water. After that, the white solid was dissolved
in 10 mL ethyl acetate and two tablespoons of a desiccant
(Na2SO4 or MgSO4) were added to the ethyl acetate to get rid of
water from the product. Finally, the solution was filtered and
evaporated under vacuum, leaving the product, which is con-
firmed by 1H NMR spectroscopy (Fig. 2).
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Conclusions
We have shown that the complex ([PdCl2(NH2CH2COOH)2]) as
a catalyst in a small amount can be used to catalyze the
Suzuki–Miyaura coupling reaction of aryl bromides containing
the carboxyl group with varieties of aryl boronic acids con-
veniently at room temperature under air in neat water, which
gives an extremely fast, highly efficient and much more green
approach to obtain biphenyl carboxylic acids (such as pharma-
ceutical intermediates, monomers of polymer materials, key
intermediates of liquid crystal compounds) that play a fairly
significant role in the field of medicine, organic synthesis,
materials chemistry. Thus, the method shows a considerable
applied and economic value because of its extremely mild con-
ditions with good functional group tolerance and excellent
yields.
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Notes and references
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J. Med. Chem., 2010, 53, 2010.
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