J.-F. Lu et al. / Tetrahedron: Asymmetry 11 (2000) 2531±2535
2535
3
.2. General procedures for the addition of AlEt to aldehydes
3
Under dry dinitrogen atmosphere, the ligand and Ti(O-i-Pr) were mixed in 1.5 mL of dry THF
4
ꢁ
at room temperature. After 1 h, AlEt (1.9 M solution in toluene) was injected at 0 C. After the
3
mixture was stirred for 30 min, the orange-colored solution was treated with aldehyde (0.5 mmol)
ꢁ
at 0 C and stayed at this temperature for 10 h, and quenched with 1N HCl. The aqueous phase
was extracted with ethyl acetate (3Â5 mL), dried over MgSO , ®ltered and concentrated. Chroma-
4
tography of the residue on silica gel (elution with 5:1 hexane:ethyl acetate) gave the carbinol.
Acknowledgements
We would like to thank the National Science Council of Taiwan for ®nancial support (NSC 89-
113-M-005-001).
2
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