Spectroscopy of Hydrothermal Reactions
J. Phys. Chem. A, Vol. 107, No. 41, 2003 8577
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Figure 2. Van’t Hoff plot of cyclization of glycylglycine to dike-
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low pressure,
while increasing the pressure to 275 bar
5
lowers the activation energy to about half that at low pressure.
At the same time, the standard enthalpy change of cyclization
of the dipeptide increases about 50 kJ/mol as pressure increases.
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peptide bond dealt with (including the thermodynamic calcula-
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the hydrolysis of polypeptide occurs via the formation of
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2,23
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1
When the kinetic method here was applied to alanine
anhydride, rate and equilibrium constants could not be obtained
because the decarboxylation rate of alanine was so slow that
the CO2 concentration could be determined only at the upper
limit of temperature and the longest residence time of the flow
reactor. However, this method of data analysis is general and
can be applied to other dipeptides provided the decomposition
(
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(decarboxylation and deamination) of the free amino acid
2
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product is monitored.
(
Acknowledgment. We are grateful to the National Science
Foundation for support of this work through Grant CHE-
(
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