ChemCatChem
10.1002/cctc.201701596
COMMUNICATION
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Kinetic isotope effect
A mixture of 1a (99 mg, 0.5 mmol), 1a-D5 (102 mg, 0.5 mmol), Langlois
reagent 2 (234 mg, 1.5 mmol), CuBr (29 mg, 0.2 mmol) and K
mg, 1.5 mmol) in MeCN (5.0 mL) in a 25 mL tube was stirred at 50 C for
h. In the end, product 4a/4a-D4 was acquired in 27% yield. 1H NMR
2 2 8
S O (405
o
3
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resolved for the trifluoromethylation reaction.
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Acknowledgements
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This work was supported by the National Natural Science Foundation of
China (No. 21376058, 21576239), the Major Scientific and Technological
Innovation Projects of Hangzhou City (No. 20162011A036). We thank Dr.
Bin Mao for helpful discussions.
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Keywords: Picolinic Acid • Trifluoromethylation • Anilines •
Coordinating Activation Strategy • Single Electron Transfer
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