Nucleosides and Nucleotides p. 981 - 992 (1993)
Update date:2022-08-11
Topics:
De Napoli
Messere
Montesarchio
Piccialli
Santacroce
2',3'-deoxy and 2',3'-dideoxy-2',3'-didehydrocytidine (d2C and d4C) have been synthesized in good yields from 2'-deoxyuridine via dichlorinated derivatives 7a-b. The same synthetic strategy was used in the synthesis of d2C(Me) and d4C(Me) from thymidine. Following this method the evaluable 3'-chloro-2'-deoxycytidine derivatives 9-12 can be easily obtained.
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