Synthetic Communications p. 395 - 403 (2019)
Update date:2022-08-17
Topics:
Derabli, Chamseddine
Boulcina, Raouf
Kirsch, Gilbert
Debache, Abdelmadjid
A variety of novel 2-alkylthiopyrimidines were synthesized through simple condensation of arylidenemalononitriles with different 2-alkylthiouronium halide derivatives catalyzed by anhydrous potassium carbonate (K2CO3). The reactions have been carried out under mild conditions in i-PrOH, and the products were obtained in moderate to good yields with a simple work-up method. Subsequently, some examples of these compounds have been converted into Tacrine analogs by applying the Friedl?nder reaction.
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