Organic Process Research and Development p. 1239 - 1245 (2016)
Update date:2022-08-11
Topics:
Toshima, Minoru
Watanabe, Shoji
Uchiyama, Katsuya
Takasaki, Tsuyoshi
Bhogle, Nandkumar N.
Zhao, Hang
Filios, Mike
Takahashi, Kazuhiko
Snoonian, John R.
Saranteas, Kostas
The process development of ethyl-(R)-3-amino-2,5-dioxopyrrolidine-3-carboxylate (2), the chiral intermediate for the manufacture of AS-3201 (1), is described. A practical and scalable Shibasaki asymmetric amination that generates the chiral quaternary center was developed and demonstrated on kilogram scale. A safe, convenient, and large-scale hydrogenation of the hydrazine intermediate was also developed.
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Doi:10.1039/c6gc02294d
(2017)Doi:10.1016/j.dyepig.2019.107710
(2019)Doi:10.1016/S0020-1693(00)82558-X
(1983)Doi:10.1007/BF00956172
()Doi:10.1021/jo00240a026
(1988)Doi:10.1039/jr9650003974
(1965)