Tetrahedron Letters (2021)
Update date:2022-08-11
Topics:
Misal, Balu
Palav, Amey
Ganwir, Prerna
Chaturbhuj, Ganesh
N-Chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI) has been explored for the first time as a chlorinating reagent for direct chlorination of various activated arenes and heterocycles without any activator. A comparative in-silico study was performed to determine the electrophilic character for NCBSI and commercially available N-chloro reagents to reveal the reactivity on a theoretical viewpoint. The reagent was prepared by an improved method avoiding the use of hazardous t-butyl hypochlorite. This reagent was proved to be very reactive compared to other N-chloro reagents. The precursor of the reagent N-(phenylsulfonyl)benzene sulfonamide was recovered from aqueous spent, which can be recycled to synthesize NCBSI. The eco-friendly protocol was equally applicable for the synthesis of industrially important chloroxylenol as an antibacterial agent.
View MoreContact:+86-25-52346955
Address:199,JIANYE ROAD,NANJING,CHINA
Qingdao XinYongAn Chemicals Co., Ltd
Contact:+86-532-81107967
Address:Chengyang dual-port industrial park by the sea,Qingdao
SuZhou Hua-Emy Chemical Import and Export Co., LTD.
Contact:+86-512-88804994; +86-512-88804550;
Address:710, Building B, International Trade Center, 12 Huanghelu, Changshu, Jiangsu,China
Alpha(shijiazhuang) Chemical Co., Ltd
Contact:+86-311-85652680
Address:Shijiazhuang City ,Hebei Province China
Anhui Eapearl Chemical Co., Ltd.
Contact:86-562-5858458
Address:358 South Huaihe Road
Doi:10.1021/jacs.7b02326
(2017)Doi:10.1016/j.bbagen.2013.09.038
(2014)Doi:10.1149/1.1470659
(2002)Doi:10.1006/jcat.1999.2584
(1999)Doi:10.1080/15257770701571768
(2008)Doi:10.1021/ic970862+
(1998)