Analytical Chemistry p. 1191 - 1195 (1987)
Update date:2022-08-17
Topics:
Einarsson, Stefan
Josefsson, Bjoern
Moeller, Per
Sanchez, Domingo
A new chiral reagent (+)-1-(9-fluorenyl)ethyl chloroformate (FLEC) was synthesized for separation of amino acid enentiomers and optically active amines.Highly fluorescent diastereomers of amino acids were obtained without racemization within 4 min at room temperature.The derivatives have favorable chromatographic properties, which is demonstrated by a reversed-phase separation of the D and L form of 17 primary amino acids in a single run.The secondary amino acids were resolved separately at a lower pH and can be determined without interferences from primary amino acids.The stability of the derivatives permitted confirmation studies with gas chromatography-mass spectrometry.
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