Green Synthesis of Flutamide
863
stirred for 50 min. The resulting mixture was extracted with CHCl , and the
3
organic layer was washed successively with dilute HCl, NaHCO3, and
brine. The organic layer was dried with anhydrous sodium sulfate, and
removal of the solvent under reduced pressure furnished the crude product,
which was purified by recrystallization from chloroform. The yield of pure
cyanuric chloride was 10 g (90%).
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