Gas Phase Peroxynitrite Reactions
Chem. Res. Toxicol., Vol. 14, No. 9, 2001 1237
in the gas phase has the same reactivity as that of the
hydroxyl radical. This requires that peroxynitrous acid,
after its formation, might diffuse into the gas phase. In
water, the homolytic cleavage of the HO-ONO bond may
produce hydroxyl radicals, or, alternatively, an activated
intermediate [ONOOH]* is formed. The similar diffusion
from water to a lipophilic environment may take place
in cells. Subsequent peroxynitrite decomposition into
radicals may cause lipid peroxidation and other oxidative
damage of membrane constituents.
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Ack n ow led gm en t. We are grateful to Prof. W. H.
Koppenol and Dr. A. J . Bailey for fruitful discussions and
their valuable comments. This work was supported by
the Ukrainian National Academy of Science and by
INTAS (Project 99-209).
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