LETTER
Synthesis of Diaryl Thioethers
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S
I
CuI
+
NH2
SH
DMSO
S
NH
1a
2d
6
S
H2O
1a/CuI
Cs2CO3
Cs2CO3
7
3a
Scheme 2 Possible mechanism
In conclusion, we have developed a novel approach to
construct diaryl thioethers, starting from aryl halides and
thioacetamide, based on a catalytic system comprised of
CuI, Cs2CO3, and DMSO–H2O. The efficiency and func-
tional-group tolerance of this procedure have been dem-
onstrated by synthesizing a number of functionalized
diaryl thioethers. Considering the inexpensive nature of
this catalytic system and the convenient availability of the
starting materials, the method described in the present re-
port may be useful in a number of fields such as pharma-
ceutical research and organic material synthesis.
Supporting Information for this article is available online at
Acknowledgment
This work was supported by the Natural Science Foundation of
Jiangsu Education Committee (10KJB150001), Open-end Funds of
Jiangsu Key Laboratory of Marine Biotechnology (No. 2009HS02),
Open-end Funds of Jiangsu Marine Resources R & D Institute
(JSIMR10C05), and Initial Fund (No. KQ09030) of Huaihai Insti-
tute of Technology.
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