Vol. 25, No. 8 (2013)
Synthesis and Antitumor Activity of 1D Coordination Polymer of Ca(II) and Na(I) 4403
Structure description: Perspective view of the molecule
in a unit cell and molecular packing arrangement are shown
in Figs. 2 and 3, respectively. It can be seen that the coordination
environment of the Ca(II) atom consists of eight oxygen atoms
from the coordinated water molecules and N-p-tolysulfonyl-
glycinate ligand, making up a distorted pseudo square
antiprismatic environment. In the complex molecule, it consists
of two different Na ions. Na1 is coordinated by six oxygen
atoms from the carboxylatos and S=O groups of N-p-tolysulfonyl-
glycinate ligand, making up a distorted octahedral environment.
Fig. 4. One dimensional chained structure of complex
Na is coordinated by five oxygen atoms from the carboxylatos
2
and S=O groups of N-p-tolysulfonyl-glycinate ligand and one
oxygen atom from the coordinated water molecules, also making
up a distorted octahedral environment. The distances of the
Ca(1)-O bonds are in the range of 2.293(5)-2.588(5) Å, which
H13B···O6, 2.827 (7) Å, symmetry code: 2-x, 2-y, 1-z; O14-
H14B···O5, 2.883 (7) Å, symmetry code: 1-x, 1-y, 1-z.
Antibacterial activity:The data of the antitumor activities
of Ca(II) complex and ligand are given in Table-3. The concen-
tration of DMSO was controlled under 1 % to assure not to
affect the results . As can be seen, the inhibitory rates of Ca(II)
complex against gastric cancer cells increased with increasing
of dose. The inhibitory effects of Ca(II) complex are higher
than that of ligand.
1
1-13
are similar to the Ca-O bond lengths reported previously
The distances of the Na(1)-O bonds are in the range of
.347(6)-2.512(6) Å and that of Na (2)-O bonds are in the
.
14
2
range of 2.324(6)-2.521(6) Å, respectively.
TABLE-3
ANTITUMOR ACTIVITY OF AGAINST
GASTRIC CANCER CELLS
-
1
Compound
Dose (µg mL )
.0
10.0
0.0
.0
10.0
0.0
Inhibitory rate (%)
16.0
5
Ca(II) complex
23.48
32.99
11.50
18.93
2
5
N-p-Tolylsulfonyl-glycine
2
24.70
ACKNOWLEDGEMENTS
The authors thank the National Natural Science Foundation
of China (No. 21171132 and 20671073), the Promotive
Research Fund for ExcellentYoung and Middle-aged Scientisits
of Shandong Province (2010BSA07004) and Science Foun-
dation of Weifang University.
Fig. 2. Molecular structure of the complex, where the thermal ellipsoids
were drawn at 30 % possibility
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