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ACS Catalysis
AUTHOR INFORMATION
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Corresponding Author
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Process. Angew. Chem., Int. Ed. 2015, 54, 4608-4611
Baxter, S.; Royer, S.; Grogan, G.; Brown, F.; Holt-Tiffin, K. E.;
Taylor, I. N.; Fotheringham, I. G.; Campopiano, D. J.; An
Improved Racemase/Acylase Biotransformation for the
Preparation of Enantiomerically Pure Amino Acids. J. Am.
Chem. Soc. 2012, 134, 19310-19313.
Schnepel, C.; Kemker, I; Sewald, N.; One-Pot Synthesis of D-
Halotryptophans by Dynamic Stereoinversion Using a Specific
L-Amino Acid Oxidase. ACS Catal. 2019, 9, 1149-1158.
Buller, A. R.; Brinkmann-Chen, S.; Romney, D. K.; Herger, M.;
Murciano-Calles, J.; Arnold, F. H.; Directed Evolution of the
Tryptophan Synthase β-Subunit for Stand-alone Function
Recapitulates Allosteric Activation. Proc. Nat. Acad. Sci. U. S. A.
2015, 112, 14599-14604.
Romney, D. K.; Murciano-Calles, J.; Wehrmuller, J. E.;
Unlocking Reactivity of TrpB: A General Biocatalytic Platform
for Synthesis of Tryptophan Analogues. J. Am. Chem. Soc.
2017, 139, 10769-10776.
Goss, R. J.; Newill, P. L. A.; A Convenient Enzymatic Synthesis
of L-Halotryptophans. Chem Commun. 2006, 0, 4924-4925.
Boville, C. E.; Romney, D. K.; Almhjell, P. J.; Sieben, M.; Arnold,
F. H.; Improved Synthesis of 4-Cyanotryptophan and Other
Tryptophan Analogues in Aqueous Solvent Using Variants of
TrpB from Thermotoga maritima. J. Org. Chem. 2018, 83,
7447-7452.
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ACKNOWLEDGMENT
The pSTB7 plasmid was kindly provided by Prof. Jason
Micklefield (University of Manchester). A.R.C. acknowledges
funding from the E.U. through the Erasmus+ programme.
R.A.C. acknowledges an Early Researcher Award from the
Ontario Ministry of Economic Development & Innovation
(ER14-10-139), and grants from the Natural Sciences and
Engineering Research Council of Canada (RGPIN-2016-04831)
and the Canada Foundation for Innovation (26503). N.J.T. is
grateful to the European Research Council for the award of
an Advanced Grant (grant no. 742987). Dr. Reynard Spiess is
kindly acknowledged for the HRMS analyses.
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