Bioorganic and Medicinal Chemistry Letters p. 3905 - 3912 (2016)
Update date:2022-08-17
Topics:
Szántó, Gábor
Makó, Attila
Vágó, István
Hergert, Tamás
Bata, Imre
Farkas, Bence
Kolok, Sándor
Vastag, Mónika
Numerous potent P2X3 antagonists have been discovered and the therapeutic potential of P2X3 antagonism already comprises proof-of-concept data obtained in clinical trials with the most advanced compound. We have lately reported the discovery and optimization of thia-triaza-tricycle compounds with potent P2X3 antagonistic properties. This Letter describes the SAR of a back-up series containing a 4-oxo-quinazoline central ring. The discovery of the highly potent compounds 51 is presented.
View MoreContact:86-311-67265101
Address:203 Lianmeng Road, Qiaoxi District
shanghai jinshan pharmaceutical Co.,Ltd
Contact:021-57363011,13681638167
Address:No. 7966 Tingfeng Road,Jinshan,Shanghai,China
Yibin Hope Pharmaceutical Co., Ltd.
Contact:+86-831-5109851 86-831-5109836
Address:Luolong Industrial Zone,Nanxi, Yibin City, Sichuan, China. | Email: wishmarketing@gmail.com | Website: http://www.hopepharma.cc/
WuHan rongfashun BioChemical co., LTD
Contact:02788866139
Address:No.95 LuoYu Road,Wuhan
Wuhan Hanye Chemical New Material Co.,Ltd
Contact:+86-27-85308141
Address:LiuDian, Panlongcheng Economic Development Zone, HuangPi district, Wuhan, Hubei 430311 P.R.China
Doi:10.1246/cl.2003.1028
(2003)Doi:10.1016/S0040-4039(98)01031-4
(1998)Doi:10.1021/jo702544g
(2008)Doi:10.1080/00304949609356532
(1996)Doi:10.1248/bpb.26.557
(2003)Doi:10.1021/ja035616d
(2003)