Bioorganic and medicinal chemistry letters (2019)
Update date:2022-08-16
Topics:
Miao, Yuhang
Sun, Jie
Wang, Xiaojing
Yang, Jie
Yun, Yinling
Alzheimer's disease (AD) is a progressive neurological degenerative disease that has complex pathogenesis. A variety of studies in humans indicate that several enzymes inhibitors can be useful in the treatment of AD, including acetylcholinesterase (AchE), butyrylcholinesterase (BuChE) and monoamine oxidase (MAO). Various substituted 4-arylcoumarin derivatives were synthesised, and their activity in vitro were investigated, including AChE/BuChE inhibitory activity, MAO inhibitory activity, and antioxidant activity. Most of the compounds were found to exhibit high inhibitory activity, and individual compounds have extremely excellent activities. Therefore 4-arylcoumarins provides an idea for drugs design for the development of therapeutic or preventive agents for AD.
View MoreShandong LuZhou Amino Acid Co., Ltd
Contact:86-539-2218025
Address:yishui economic and technical development zone zhenxing south road
Ningbo Hi-tech Zone Nice-Synth Chemical Industry Ltd.
Contact:+86-(574)-81110986
Address:No. 1210, Building 3, Wante Business Centre, Hi-tech Zone, Ningbo
Hangzhou Dawn Ray Pharmaceutical Co.,Ltd
website:http://www.dawnraypharma.com/
Contact:+86-571-85335020
Address:1018 Guangyin Building,No.42 E.Fengqi Road,Hangzhou,310012 China
Beijing Huikang Boyuan Chemical Tech Co.,LTD
Contact:+86-10-68862197
Address:No.7 Haiying Road,Science City,Fengtai District,Beijing,China
TIANJIN NORTH JINHENG CHEMICAL PLANT.
Contact:0086-22-59952083
Address:DongShigu Country In JiXian TianJin China
Doi:10.1135/cccc19920119
(1992)Doi:10.1021/jo01268a095
(1968)Doi:10.1039/c4ra08219b
(2014)Doi:10.1021/jo981846c
(1999)Doi:10.1039/jr9510002480
(1951)Doi:10.1016/j.bmc.2019.115252
(2020)