Journal of Inclusion Phenomena and Macrocyclic Chemistry
4. Gao, E.Q., Tang, J.K., Liao, D.Z., Jiang, Z.H., Yan, S.P., Wang,
G.L.: A new class of heterobinuclear complexes: crystal structure
and magnetism of copper (II)-nickel (II) complexes Incorporating
two different macrocyclic ligands. Helv. Chim. Acta 84, 908–917
(2001)
Conclusions
Metal complexes of Mn(II), Co(II), Ni(II), Cu(II), and
Zn(II) with macro cyclic ligands (LO) and (LM) L [N,N′-
bis(2-aminoethyl)hexanediamide] were synthesized and
characterized using FTIR, UV, 1H NMR, mass spectroscopy,
molar conductivity and elemental analysis. All the com-
plexes are colored, stable in air and insoluble in water and
common solvents but soluble in a polar solvent like DMF
and DMSO. Thermal analysis showed that the ligand L as
well as macro-cyclic ligands showed maximum weight in
common steps in comparison to all metal complexes, which
were found to be more thermally stable than their parental
ligands. Antimicrobial activity results showed that all metal
complexes exhibited a higher degree of activity as compared
with the parent ligands against the same microorganism and
under the identical experimental conditions. This is due to
the fact that on chelation the polarity of the metal ion will
be reduced to a greater extent due to the overlap of ligand
orbital and partial sharing of the positive charge of the metal
ion with donor atoms. Further, it increases the delocaliza-
tion of p-electrons over the whole chelate ring and enhances
the lipophilicity of the complexes. This increased lipophi-
licity enhances the penetration of the complexes into the
lipid membranes and blocks the metal binding sites in the
enzymes of microorganism.
5. Tang, J.K., Wang, Q.L., Gao, E.Q., Chen, J.T., Liao, D.Z., Jiang,
Z.H., Cheng, P.: First crystal structure of a (µ-oxamidato) tricop-
per (II) metal (II)-type tetranuclear complex: synthesis, crystal
structure, and magnetism of a copper (II) manganese (II) complex
([CuII3MnII (µ-L) 3](N3) 2⋅ EtOH) incorporating a macrocyclic
oxamide ligand L (macrocyclic oxamide = 1, 4, 8, 11-tetraazacy-
clotetradecane-2, 3-dione). Helv. Chim. Acta 85, 175–182 (2002)
6. Sibert, J.W., Cory, A.H., Cory, J.G.: Lipophilic derivatives of
Kovacs, Z., Kodadek, T., Sherry, A.D.: Magnetic resonance
imaging detects a specific peptide-protein binding event. J. Am.
Chem. Soc. 124, 3514–3515 (2002)
8. Caravan, P., Ellison, J.J., McMurry, T.J., Lauffer, R.B.: Gado-
linium (III) chelates as MRI contrast agents: structure, dynam-
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9. Beeby, A., Bushby, L.M., Maffeo, D., Williams, J.G.: Intra-
molecular sensitisation of lanthanide (III) luminescence by
acetophenone-containing ligands: the critical effect of para-
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11. Shih, H.C., Tang, N., Burrows, C.J., Rokita, S.E.: Nickel-based
probes of nucleic acid structure bind to guanine N7 but do not
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Acknowledgements The authors Shahnawaz Ahmad Bhat, Abdul
kareem and Azar Ullah Mirza thanks University Grants Commission
(Grant No. 2015), New Delhi, for the financial support, and thankful
to Department of Chemistry, Jamia Millia Islamia, New Delhi and
Central Instrumentation facility, Jamia Millia Islamia, New Delhi for
providing necessary facilities.
unprecedented coordination mode for hemilabile pendant-arm 1,
4, 7-triazacyclononanes and the synthesis of cationic organoalu-
minium complexes. Chem. Commun. 1269, 1269–1270 (2000)
14. Ehrlich, L.A., Skrdla, P.J., Jarrell, W.K., Sibert, J.W., Armstrong,
N.R., Saavedra, S.S., Barrett, A.G., Hoffman, B.M.: Preparation
of polyetherol-appended sulfur porphyrazines and investigations
of peripheral metal ion binding in polar solvents. Inorg. Chem.
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