Bioorganic Chemistry p. 42 - 48 (2015)
Update date:2022-08-25
Topics:
Rahim, Fazal
Malik, Fazal
Ullah, Hayat
Wadood, Abdul
Khan, Fahad
Javid, Muhammad Tariq
Taha, Muhammad
Rehman, Wajid
Ur Rehman, Ashfaq
Khan, Khalid Mohammed
Isatin base Schiff bases (1-20) were synthesized, characterized by 1H NMR and EI/MS and evaluated for α-glucosidase inhibitory potential. Out of these twenty (20) compounds only six analogs showed potent α-glucosidase inhibitory potential with IC50 value ranging in between 2.2 ± 0.25 and 83.5 ± 1.0 μM when compared with the standard acarbose (IC50 = 840 ± 1.73 μM). Among the series compound 2 having IC50 value (18.3 ± 0.56 μM), 9 (83.5 ± 1.0 μM), 11 (3.3 ± 0.25 μM), 12 (2.2 ± 0.25 μM), 14 (11.8 ± 0.15 μM), and 20 (3.0 ± 0.15 μM) showed excellent inhibitory potential many fold better than the standard acarbose. The binding interactions of these active analogs were confirmed through molecular docking.
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