Journal of Fluorine Chemistry (2020)
Update date:2022-08-29
Topics:
?im?nek, Ond?ej
Rybá?ková, Markéta
Svoboda, Martin
Kví?ala, Jaroslav
PEPPSI complexes are air and moisture stable Pd catalysts, which can be used conveniently in many coupling reactions. With the aim to obtain Pd catalysts recyclable by fluorous separation methods, we modified the structure of commercial PEPPSI complexes by per- or polyfluoroalkylation in various positions. The modifications included the use of a linear polyfluoroalkyl group instead of one aryl group on the NHC ligand, perfluoroalkylation of pyridine ligand, and substitution of chloride ligands on Pd for perfluoroalkanoates or perfluoropolyoxaalkanoates. Comparison of catalytic activity of commercial catalysts with the modified ones in Suzuki-Miyaura cross-coupling reactions showed that the fluorous modifications mostly resulted in the increase of catalytic activity. Moreover, polyfluoroalkylation enabled efficient medium fluorous recycle of the modified catalysts using a two phase aqueous DMF/HFE 7500 ether system.
View MoreGuangxi Shanyun Biochemical Science and Technology Co., Ltd
Contact:+86-0772--6828887
Address:#2 Industrial Park of Luzhai County, Liuzhou, Guangxi, China
Contact:18698110882
Address:1303 No2 building,LuoMa Garden,YongAn Road,Hexi District,Tianjin city
GUANGZHOUGRENSPSPORTS FACILITIES CO LTD
Contact:
Address:
Anhui Redstar Pharmaceutical Corp., Ltd
Contact:+86-563-5120837
Address:Jingxian Industrial Development Zone, Anhui , China
Shanghai Balmxy Pharmaceutical Co., Ltd
Contact:0086-21-24206007
Address:Room 402, 15#, No. 909 wangyue Road, shanghai, P. R. China
Doi:10.1080/14756366.2017.1355791
(2017)Doi:10.1021/ja01313a067
(1935)Doi:10.1021/ja00388a051
(1982)Doi:10.1007/s10973-005-0058-2
(2005)Doi:10.1021/ja01042a050
(1969)Doi:10.1016/S0968-0896(02)00314-0
(2002)