Synthetic Communications p. 367 - 376 (2019)
Update date:2022-08-25
Topics:
Becerra-Rivas, Christian
Cuervo-Prado, Paola
Orozco-Lopez, Fabian
A series of spirocyclohexane-1,4′-pyrazolothiazepinones were synthesized by one-pot multicomponent cyclocondensation reactions between 5-amino-1-arylpyrazoles, cyclohexanone and mercaptoacetic acid with good yields and easy purification protocols. Some control experiments involving isolation of reaction intermediates were performed leading to the proposal of three alternative mechanistic pathways conducting to the named spiroheterocycles. All target molecules were fully characterized by IR, NMR, melting point and HRMS.
View Morewebsite:http://www.alwaychem.com
Contact:+86-532-8586-4000, 8586-5000
Address:NO.51, TAIPING ROAD, QINGDAO, CHINA. 266001
Yixing Bluwat Chemicals Co., Ltd.
Contact:+86 510 87821568
Address:Yongan Road, Yixing Chemical Industrial Park, Yixing, Jiangsu, China
Jinan Yufeng Bioengineering Co., Ltd.
Contact:+86-531-83130545/83130528/83130525/83130505
Address:Rm415,Building2,No19,Huaneng Road,Jinan, Shandong, China
JiangXi Keyuan Biopharma Co., LTD.
Contact:+86-563-6833666
Address:Guangde Fine Chemical Zone, Anhui Province, China
Shanghai Massive Chemical Technology Co., Ltd.
website:http://www.massivechem.com/
Contact:+86 21 34943721
Address:Room 435, 4th floor, Building 9, No. 2568 Gudai Road,Minhang District, Shanghai,
Doi:10.1039/c4gc00098f
(2014)Doi:10.1021/jo00984a031
(1972)Doi:10.1002/poc.894
(2005)Doi:10.1002/aic.690140607
(1968)Doi:10.1016/j.tet.2014.11.004
(2014)Doi:10.1016/0022-4596(88)90257-5
(1988)