All major chemicals were obtained from commercial sources and used without further purification. All
reactions were monitored by TLC. Column chromatography was performed on silica gel.
General procedure: A sealable reaction tube equipped with a magnetic stirrer bar was charged with
aldehydes (1.0 mmol), amines (1.2 mmol), CuI (0.1 mmol), tert-butyl hydroperoxide (TBHP, 2.0 mmol),
water (1 mL). The reaction vessel was carried out at room temperature. After stirring the mixture for 6 h, it
was diluted with ethyl acetate, washed with water and brine, dried with Mg2SO4. After the solvent was
removed under reduced pressure, the residue was purified by column chromatography on silica gel using
petroleum ether/ethyl acetate as eluent to afford the corresponding product.
Acknowledgment
The National Natural Science Foundation of China (No. 21402103), the China Postdoctoral Science
Foundation (No. 150030), the Scientific Research Foundation of Shandong Province Outstanding Young
Scientist Award (No. BS2013YY024) and the research fund of Qingdao Agricultural University’s High-
level Person (No. 631303) were gratefully acknowledged.
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