Tetrahedron Letters p. 7099 - 7102 (1996)
Update date:2022-08-17
Topics:
Shinada, Tetsuro
Miyachi, Miki
Itagaki, Yasuhiro
Naoki, Hideo
Yoshihara, Kazuo
Nakajima, Terumi
A facile synthesis of 6-hydroxyindole-3-acetic acid 1a, which is the proposed aromatic subunit of NPTX-1~6, is described. Radical cyclization of isonitrile 2 successfully afforded 9 in high yield. The aromatic subunit of NPTX-1~6 was confirmed as 4-hydroxyindole-3-acetic acid 12 by comparison of the 1H-NMR spectra with those of authentic 4- and 6-hydroxyindole-3-acetic acids.
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