10.1002/ejoc.202000311
European Journal of Organic Chemistry
COMMUNICATION
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Experimental Section
General procedure for electrochemical synthesis of 2,5-
disubstituted 1,3,4-oxadiazoles: In an oven-dried undivided
three-necked flask (25 mL) equipped with
a
stir bar,
acylhydrazines 1 (0.50 mmol), α-keto acids 2 (1.0 mmol),
anhydrous CH3OH (11 mL) with nBu4NOAc (1.0 equiv., 150.7 mg)
as an electrolyte were combined and added. The flask was
equipped with platinum electrodes (1.5 cm×1.5 cm×0.3 mm) as
cathode, graphite rod (Φ 6 mm, about 15 mm immersion depth
in solution) as the anode and was then charged with nitrogen.
The reaction mixture was stirred and electrolyzed at a constant
current of 12 mA under room temperature for 3 h. After
completion of the reaction, as indicated by TLC and GC-MS, the
pure product was obtained by flash column chromatography on
silica gel (petroleum ether : ethyl acetate = 20 : 1).
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Acknowledgements
This work was supported by the National Natural Science
Foundation of China (21702081, 21702150), China Postdoctoral
Science Foundation (BX201600114, 2016M602340).
Keywords: Electrochemical •2,5-disubstituted 1,3,4-oxadiazoles
• Metal free • External oxidant free
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