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Journal Name
COMMUNICATION
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DOI: 10.1039/C6CC01312K
2 (a) Y. Hatanaka and T. Hiyama, J. Org. Chem., 1988, 53, 918-
In summary, a highly efficient C(sp )-C(sp ) cross-coupling of
Knochel and R. D. Singer, Chem. Rev., 1993, 93, 2117-2188.
Ln(CH SiMe ) (THF) with aryl bromides had been developed
2
3 3
2
1
1
for the construction of functionalized benzyltrimethylsilanes.
This reaction was conducted at room temperature in the
presence of only 0.5 mol% Pd (dba) /4XPhos and exhibited
9
20. (b) E. Hagiwara, K.-I. Gouda, Y. Hatanaka and T. Hiyama,
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2
3
(d) S. E. Denmark and C. S. Regens, Acc. Chem. Res., 2008, 41
1486-1499.
,
broad substrate scope. The functionalities in these ArCH SiMe3
2
products provide a handle for further functionalization.
Furthermore, these silanes can be transformed into olefins,
aldehydes, acylsilanes, alcohols and amines by Peterson
3 (a) D. Azarian, S. S. Dua, C. Eaborn and D. R. M. Walton, J.
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6, 1423-1424. For
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olefination, photocatalyzed or gold-catalyzed reactions,
,
27
5
and fluoride-mediated addition reactions . The application of
this reaction as the key step in total synthesis of natural
products is under way.
All authors have given approval for the final version of the
manuscript. The authors declare no competing financial
interest. We thank the National Natural Science Foundation of
China (21274012, 21322401 and 21490570) and Beijing
Institute of Technology (the 111 Project B07012) for financial
support.
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4 For recent reviews, see: (a) R. Jana, T. P. Pathak and M. S.
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0
, 160-170. (e) X. Li and Z. Hou, Macromolecules, 2010, 43
,
Notes and references
8904-8909.
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1
6 Syntheses of ArCH SiMe by the reaction of LiCH SiMe with
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2
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0 Syntheses of ArCH SiMe by the reaction of Me SiCH MgCl
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3
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2
3
3
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