5
6
S.D. Dindulkar et al. / Journal of Molecular Structure 990 (2011) 44–56
4
. Conclusions
compounds 14–26 are provided. Yields and melting points are
Thirteen novel N-benzylated 3-alkyl-2,6-diarylpiperidin-4-ones
1
4–26 were conveniently synthesized in high yields 87–92% and
1
13
characterized by their analytical and spectral data. The H/
C
NMR spectral/stereochemical assignments have been unambigu-
References
1
1
1
13
ously carried out by use of HA H COSY, HA C COSY and NOESY
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associated protons. On the other hand, irrespective of the nature
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C-2/C-6, all compounds 14–26 exist in a chair conformation with
equatorial orientation of the substituents at C-2, C-3, C-6 and N. Be-
side the impact on chemical shifts of 26 by the introduction of
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Acknowledgement
3
This research work was supported by the Industrial Technology
Development Program, which was conducted by the Ministry of
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Appendix A. Supplementary material
[
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All crystallographic parameters and data of 22 are provided. The
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from the Cambridge Crystallographic Data Centre www.ccdc.cam.
ac.uk/conts/retrieving.html. Mass spectra of all the N-benzylated
[
[
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[
[
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