European Journal of Medicinal Chemistry p. 187 - 197 (2016)
Update date:2022-08-17
Topics:
Serpe, Loredana
Ellena, Silvano
Barbero, Nadia
Foglietta, Federica
Prandini, Federica
Gallo, Maria Pia
Levi, Renzo
Barolo, Claudia
Canaparo, Roberto
Visentin, Sonja
We report the synthesis and characterization of a series of symmetrical indolenine-based squaraine dyes along with the evaluation of their singlet oxygen generation efficiency. The photodynamic activity of these new photosensitizers has been evaluated on a human tumor fibrosarcoma (HT-1080) cell line. The cytotoxicity increased over time and is induced by the photoactivation of bromo (Br-C4) and iodio (I-C4) long carbon chain squaraine dyes and the consequent increase in reactive oxygen species (ROS) production (p < 0.001), which leads to necrosis 6 h after treatment. Induction of cytochrome c release, DNA damage and up-regulation of GPX1, NQO1 and SOD2 mRNA gene expression after PDT were investigated.
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