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Fig. 5 Cell viability of A549 cells after treatment with (a) BOD-1 and (b)
BOD-2 at different concentrations. The control group was incubated only
with the cell culture medium. (c) Effect of light dose on cell viability (BOD-1
and BOD-2, green LED, 525 nm, 3.3 W cmÀ2, 80 nM).
throughout the incubation process showed relatively no
decrease in cell viability up to 200 nM, thereby demonstrating
the great cellular biocompatibility of the photosensitiser.19
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In conclusion, we reported a new generation of halogenated
BODIPY-based photosensitisers, which demonstrated excellent
photoactivity and photocytotoxicity both in solution and living
cells. The significant increase in FD confirms that incorporating
bromine atoms into the vinyl backbone of a BODIPY skeleton was
an efficient means to transform a non-active BODIPY dye into a
highly active triplet sensitiser. The triplet excited state lifetimes of
the photosensitisers were in the range of 101 to 145 ms. Significant
upconversion was observed for BOD-2 when combined with
perylene as the triplet acceptor, with upconversion quantum
yields up to 4.88%. The photosensitiser that we developed,
BOD-1, was far more photoactive than the widely used 2,
6-dibromo BODIPY derivatives and relatively more emissive than
their corresponding 2,6-diiodo analogues, thereby making it a
highly promising tool for imaging-guided PDT.
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˙
16 (a) S. Dartar, MSc. Thesis, Izmir Institute of Technology, 2019;
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There are no conflicts to declare.
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6042 | Chem. Commun., 2021, 57, 6039–6042
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