Synthetic Communications p. 263 - 274 (2016)
Update date:2022-08-10
Topics:
Devarasetty, Kiran
Tharikoppula, Giri
Sridhar, Tailor
Eppakayala, Laxminarayana
Kyasani, Mahesh
Arumugam, Premkumar
Pusuluri, Srinivas
A series of novel 2-alkylamino and 2, 4-dialkyl amino 6-oxopyrimidin-1(6H)-yl) benzamide derivatives were prepared in good yields from a base-catalyzed ring opening of oxadiazolo[3,2-a]pyrimidin-5-one and evaluated for their antibacterial and cytotoxicity. Most of the compounds exhibited antibacterial activity. In particular, compounds 5b and 5k exhibited considerable antibiotic activity against Klebsiella pneumonia and Bacillus cereus. In addition, compounds 5g and 5i also inhibited the growth of two human tumor cell lines (A549 and H460) at micromolar concentrations.
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