Bioorganic and Medicinal Chemistry Letters p. 1577 - 1582 (1997)
Update date:2022-08-15
Topics:
Meier, Chris
Knispel, Tina
De Clercq
Balzarini, Jan
The synthesis of lipophilic pro-nucleotides of ddAMP 2 based on cycloSal-ddAMP 3a-c is described. Phosphotriesters 3 released ddAMP 2 selectively by a controlled, chemically induced tandem reaction. CycloSal-phosphotriesters 3 exhibited antiviral activity against HIV-1/HIV-2 in CEM cells that where by a factor up to hundred higher as compared to ddA 1.
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