2
6
A.V. Biradar et al. / Applied Catalysis A: General 389 (2010) 19–26
tivity. These catalytic systems may provide “greener” routes to a
large scale production of industrially and pharmaceutically impor-
tant products with less byproduct in the chemical industry of the
next millennium. We believe that with minor additional reac-
tor engineering involving scale ups, these catalytic bed reactors
may become industrially viable substitutes to the current state-of-
the-art commercial catalysts for the Henry and related reactions
involving soluble bases such as KOH, NaOH, KH PO , Na CO , and
NEt3 [44]. The latter are in homogenous phase and are, there-
fore, difficult to separate from the final products compared to a
simple filtration necessary to do so for typical heterogeneous cat-
alysts, as the ones reported here. Furthermore, the homogenous
catalysts are known to result in a mixture of nitroalcohol and
nitrostyrene products with lower selectivities. With our experi-
mental demonstration of continuous catalytic transformations of
the Henry reaction with unaltered catalytic efficiency for over
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