Synthetic Communications p. 278 - 290 (2009)
Update date:2022-08-30
Topics:
Reddy, Ganta Madhusudhan
Mukkanti, Kaga
Bhaskar, Boluggodu Vijaya
Reddy, Padi Pratap
Rabeprazole sodium (Aciphex) is a gastric proton pump inhibitor used for the prevention and treatment of gastric acid-related diseases. During the synthesis of bulk drug of rabeprazole sodium, we have observed metabolites rabeprazole sulfide and rabeprazole sulfone and related substances rabeprazole-N-oxide, rabeprazole sulfone-N-oxide, N-aralkyl rabeprazole, chloro rabeprazole, and methoxy rabeprazole as impurities in the drug substance. The present work describes the synthesis and characterization of these compounds. Copyright Taylor & Francis Group, LLC.
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