Organic Letters
Letter
Scheme 6. Possible Mechanism for the Formation of 3 and 4
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quinolones and 1-vinyl-3-carboxylate-4-quinolones by changing
the base in the reaction. The easily accessible starting materials,
mild reaction conditions, and simple manipulation render this
an attractive methodology. Further applications of this isatin-
based oxidative cyclization strategy for the synthesis of other
interesting heterocycles are currently underway in our
laboratory.
ASSOCIATED CONTENT
* Supporting Information
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S
The Supporting Information is available free of charge on the
Experimental procedures, product characterizations,
1
crystallographic data, and copies of the H and 13C
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Accession Codes
mentary crystallographic data for this paper. These data can be
contacting The Cambridge Crystallographic Data Centre, 12
Union Road, Cambridge CB2 1EZ, UK; fax: +44 1223 336033.
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AUTHOR INFORMATION
Corresponding Authors
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ORCID
Author Contributions
§S.-F.J. and C.X. contributed equally.
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
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1980, 19, 222. (b) Reissenweber, G.; Mangold, D. Angew. Chem., Int.
Ed. Engl. 1981, 20, 882.
We are grateful to the National Natural Science Foundation of
China (Grant Nos. 21472056, 21602070, and 21772051) and
the Fundamental Research Funds for the Central Universities
(CCNU15ZX002 and CCNU16A05002) for financial support.
This work was also supported by the 111 Project B17019.
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