Journal of Organic Chemistry p. 11441 - 11449 (2019)
Update date:2022-08-30
Topics:
Chaudhuri, Amrita
Venkatesh, Yarra
Das, Joyjyoti
Gangopadhyay, Moumita
Maiti, Tapas K.
Singh, N. D. Pradeep
Persulfides have been considered as potential signaling compounds similar to the H2S in "S-persulfidation", a sulfur-mediated redox cycle. The research of this sulfur-mediated species is hindered because of the lack of efficient persulfide donors. In this current study, we have developed one- and two-photon-activated persulfide donors based on an o-nitrobenzyl (ONB) phototrigger, which releases the biologically active persulfide (N-acetyl l-cysteine persulfide, NAC-SSH) in a spatiotemporal manner. Next, we have demonstrated the detection of persulfide release both qualitatively and quantitatively using the well-known "turn on" fluorescence probe, that is, monobromobimane, and the trapping agent, that is, 2,4-dinitrofluorobenzene, respectively. Furthermore, we examined the cytotoxicity of synthesized persulfide donors on HeLa cells and the cytoprotective ability in the highly oxidizing cellular environment.
View MoreZhejiang Genebest Pharmaceutical Co.,Ltd.
Contact:0086-571-63532866
Address:No.1 Jinboshi Rd Lishan Town Fuyang City Zhejiang Province China
Contact:86-607-68073220
Address:1 ave na road jiahua st
Evergreen Chemical Industry Ltd.
Contact:86-553-4918210
Address:6#2-602 Wanhaobailing
YingYing Pharmaceutical Co.,Ltd
Contact:86-18854126208
Address:55#, yingxiongshan road
Arshine Pharmaceutical Co., Limited
website:http://www.cnarshine.com
Contact:0731-88503671
Address:Room 1109.Block C3, Lugu Enterprise Plaza,No.27 Wenxuan Road,Changsha National Hi-Tech Industrial Development Zone,Hunan ,P.R.China
Doi:10.1002/1521-3765(20020603)8:11<2476::AID-CHEM2476>3.0.CO;2-E
(2002)Doi:10.1002/kin.20016
(2004)Doi:10.1016/j.ica.2011.02.042
(2011)Doi:10.1021/ja01579a030
(1957)Doi:10.1021/acs.joc.5b02378
(2016)Doi:10.1016/j.foodchem.2019.01.194
(2019)