Tetrahedron p. 7883 - 7890 (1998)
Update date:2022-08-11
Topics:
Cipiciani, Antonio
Cittadini, Massimiliano
Fringuelli, Francesco
Racemic methyl 2-(2,4-dichlorophenoxy)propionate (±)-1, was subjected to hydrolysis in water and in a series of two-phase aqueous organic media in the presence of Candida rugosa lipase (CRL). The biocatalytic material used was the commercial preparation and enzyme purified by using different procedures. The (+)-R- and (-)-S-2-(2,4-dichlorophenoxy)propionic acids (3) were obtained in excellent yield and high enantiomeric excess when the hydrolysis of (}-1 was performed in water/benzene in the presence of 2- propanol treated CRL. The kinetic resolution of (±)-1 was scaled-up.
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