BULLETIN OF THE
Article
Development of Hydrogel Lenses with Surface-immobilized PEG Layers
KOREAN CHEMICAL SOCIETY
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Conclusion
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Novel tri-branched PEG-substituted benzohydrazides were
synthesized and used as building blocks for the preparation
of protein-resistant hydrogels via surface modifications. The
PEG-modified hydrogels exhibited high transparency and
improved surface hydrophilicity compared to the untreated
hydrogels. The PEG coating was proven to successfully
reduce the adsorption of lysozyme onto the hydrogel surfaces
because of their bioinert and highly hydrophilic nature. Nota-
bly, the tri-branched PEG treatment reduced the lysozyme
adsorption with greater efficiency compared to linear PEGs.
This result is attributed to the characteristic structural features
of branched PEGs, which combine a highly flexible polyether
with hydrophilic surface groups and a highly branched archi-
tecture, resulting in a strong steric hindrance, which repels the
approaching lysozyme efficiently. The preparation of hydro-
gels with a PEG-immobilized surface may be a new method
for the development of ophthalmic biomaterials as well as
protein-resistant devices.
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Acknowledgments. This study was supported by research
funds provided by Chosun University in 2013.
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Bull. Korean Chem. Soc. 2015, Vol. 36, 2682–2687
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