Tetrahedron Letters p. 4333 - 4336 (1988)
Update date:2022-08-10
Topics:
Clark, J. Stephen
Holmes, Andrew B.
The asymmetric synthesis of the laurencin degradation product (2) by methylenation of the chiral heptanolide (5), conformationally controlled hydroboration of the enol ether (6), to give exclusively the cis-alcohol (7), and introduction of the pentyl side chain, demonstrates a new approach to the enantioselective synthesis of 2,8-disubstituted oxocanes, and confirms the absolute configuration of laurencin (1).
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