ChemMedChem
10.1002/cmdc.202100157
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Experimental Section
The experimental details, including the synthesis and characterisation of
Pt1-Pt14 and Pd1, the protocols for the in vitro and in vivo assays have
been described in the supporting information.
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Acknowledgements
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This study was performed in strict accordance with The Australian
Code for the Responsible Conduct of Research (2018). ATCC
yeast and bacteria strains, and HEK-293 cells were acquired from
the American Type Culture Collection (ATCC). Human blood was
sourced from the Australian Red Cross Blood Service with
informed consent and its use in haemolysis assays was approved
by The University of Queensland Institutional Human Research
Ethics Committee, Approval Number 2014000031. The
antimicrobial screening performed by CO-ADD (The Community
for Antimicrobial Drug Discovery) was funded by the Wellcome
Trust (UK; Strategic Funding Award: 104797/Z/14/Z) and The
University of Queensland (Australia; Strategic Funding Award).
A.F. thanks the Swiss National Science Foundation for Support
by an Early Postdoc. Mobility fellowship (P2ZHP2_177997).
M.A.T.B., A.G.E., J.Z. S.R. and G.L. are supported in part by
Wellcome Trust Strategic Grant WT1104797/Z/14/Z. A.K.C was
supported by an Australian Research Council (ARC) DECRA
fellowship (DE180100929). Furthermore, we acknowledge
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Keywords: antibiotic • metals in medicine • metalloantibiotic •
inorganic medicinal chemistry • platinum
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