Nucleosides, nucleotides and nucleic acids p. 533 - 545 (2018)
Update date:2022-08-16
Topics:
Castiglioni, Sara
Romeo, Valentina
Casati, Silvana
Ottria, Roberta
Perrotta, Cristiana
Ciuffreda, Pierangela
Maier, Jeanette A. M.
N6-isopentenyladenosine is an anti-proliferative and pro-apoptotic atypical nucleoside for normal and tumor cells. Considering the role of angiogenesis in various diseases, we investigated the cytotoxic effect of N6-isopentenyladenosine on human microvascular endothelial cells, protagonists in angiogenesis. Our results show that N6-isopentenyladenosine induced a significant reduction of cell viability, upregulated p21 and promoted caspase-3 cleavage in a dose dependent manner leading to apoptotic cell death as detected by FACS analysis. To understand structure-function relationship of N6-isopentenyladenosine, we investigated the effect of some N6-isopentenyladenosine analogs. Our results suggest that N6-isopentenyladenosine and some of its derivatives are potentially novel angiostatic agents and might be associated with other anti-angiogenic compounds for a better outcome.
View MoreContact:86-571-86737118-8689
Address:No.69, 12 Street, HEDA, Hangzhou, Zhejiang, China
QINGDAO NEW FLOURISH INTERNATIOANAL TRADE CO., LTD.
Contact:+86 532 80861829
Address:No. 1, Yinchuan East Road, 266061, Qingdao, China
Purestar Chem Enterprise Co.,Ltd
website:http://www.purestarchem.com
Contact:05722157374
Address:no235.huanchengdong Rd
Shanghai Sunwise Chemical Co., Ltd
website:http://www.sunwisechem.com
Contact:86-021-33883180
Address:Room 10E, Building G, Westlink Center, No. 2337 Gudai Road, Minhang District, Shanghai, China PC: 201100
Shanghai Sharing technologies Co., Ltd.
Contact:86-021-66787223
Address:No11, Lane 225, Jinxiang Road,Pudong district
Doi:10.1007/s11164-019-03881-6
(2019)Doi:10.1016/S0040-4039(00)77486-7
(1993)Doi:10.1016/0022-4596(89)90038-8
(1989)Doi:10.1002/chem.201602237
(2016)Doi:10.1039/d0ta06673g
(2020)Doi:10.1002/jhet.2389
(2016)