LETTER
A One-Pot Three-Component Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones
1157
In conclusion, a novel one-pot three-component method
for the synthesis of 2,3-dihydroquinazolinones is report-
ed. High yields, ease of work up procedure, use of cheap
and commercially available starting materials, convenient
manipulation, and mild reaction conditions are the advan-
tages of this new method. We believe that the present
methodology addresses the current drive toward green
chemistry due to high yields, atomic economy and reus-
ability of the catalyst.
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General Procedure for the Synthesis of 2,3-Dihydroquinazolin-
4
(1H)-ones
To a solution of isatoic anhydride (1 mmol), amine (1.2 mmol) or
NH ) CO (0.7 mmol) and aldehyde (1 mmol) in EtOH (5 mL) was
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(
4
2
3
added a catalytic amount of silica sulfuric acid (0.11 g = 0.3 mmol
+
of H ). The solution was heated under reflux for the specified period
of time (Tables 1 and 2). After completion of the reaction as indi-
cated by TLC (EtOAc–n-hexane, 1:2), the solid catalyst was sepa-
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rated by filtration. H O (5 mL) was added and the precipitated
2
product was filtered, and recrystallised from EtOH.
(
Acknowledgement
3169. (b) Armstrong, R. W.; Combs, A. P.; Tempest, P. A.;
Brown, S. D.; Keating, T. A. Acc. Chem. Res. 1996, 29, 123.
We are grateful to Shahid Beheshti University Research Council for
partial support of this work.
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(
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