Synthetic Communications p. 4452 - 4459 (2008)
Update date:2022-08-16
Topics:
Singamsetty, Radha Krishna
Vujjini, Satish Kumar
Manne, Nagaraju
Venkata Naga, Brahmeshwara Rao Mandava
Himabindu, Vurimidi
Battacharya, Apurba
Ghanta, Mahesh Reddy
Bandichhor, Rakeshwar
A noninfringing synthesis of simvastatin 1, starting from lovastatin 2, is presented. This synthesis features the protection of the free hydroxyl group of the lovastatin with 3,4-dihydro-2H-pyran (DHP) and opening of the lactone ring with n-BuNH2 to afford amide 4 as a key intermediate. Copyright Taylor & Francis Group, LLC.
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