Journal of the American Chemical Society
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Li, B.; Kawatkar, S. P.; George, S.; Strachan, H.; Woods, R.
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J.; Siriwardena, A.; Moremen, K. W.; Boons, G.-J. Inhibition of Golgi
Mannosidase II with Mannostatin A Analogues: Synthesis, Biological
*
Evaluation,
ChemBioChem 2004, 5 (9), 1220-1227.
4. Popowycz, F.; Gerber-Lemaire, S.; Demange, R.;
Rodriguez-Garcıa, E.; Asenjo, A. T. C.; Robina, I.; Vogel, P.
Derivatives of (2R,3R,4S)-2-Aminomethylpyrrolidine-3,4-diol are
selective α-Mannosidase inhibitors. Bioorganic Medicinal
Chemistry Letters 2001, 11 (18), 2489-2493.
5. Fiaux, H.; Kuntz, D. A.; Hoffman, D.; Janzer, R. C.; Gerber-
and
Structure-Activity
Relationship
Studies.
ACKNOWLEDGMENT
We thank the Netherlands Organization for Scientific Research
(NWO; TOP grant to H.S.O.), the European Research Council
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(ERC-2011-AdG-290836 ‘Chembiosphing’ to H.S.O., and ERC-
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012-AdG-32294 ‘Glycopoise’ to G.J.D.), and the Biotechnology
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and Biological Sciences Research Council (BBSRC;
BB/R001162/1 and BB/M011151/1 grants to G.J.D.). GJD thanks
the Royal Society for the Ken Murray Research Professorship.
Lemaire, S.; Rose, D. R.; Juillerat-Jeanneret, L. Functionalized
pyrrolidine inhibitors of human type II α-mannosidases as anti-cancer
agents: Optimizing the fit to the active site. Bioorganic & Medicinal
Chemistry 2008, 16 (15), 7337-7346.
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ABBREVIATIONS
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6.
Fiaux, H.; Popowycz, F.; Favre, S.; Schütz, C.; Vogel, P.;
GMII; Golgi α-mannodiase II, LAM; Lysosomal α-mannosidase,
Epman; Epididymis-specific α-mannosidase, MU-α-Man; 4-
methylumbelliferyl α-D-mannoside
Gerber-Lemaire, S.; Juillerat-Jeanneret, L. Functionalized Pyrrolidines
Inhibit α-Mannosidase Activity and Growth of Human Glioblastoma
and Melanoma Cells. Journal of Medicinal Chemistry 2005, 48 (13),
4
237-4246.
7. Cheng, T.-J. R.; Chan, T.-H.; Tsou, E.-L.; Chang, S.-Y.;
1
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