Synthetic Communications p. 2857 - 2862 (2004)
Update date:2022-08-10
Topics:
Puri
Handa
Dhar
Suri
Qazi
The use of dichloromethane as a reagent, for the preparation of Topotecan {(45)-10-(dimethylamino)methyl-4-ethyl-4,9-dihydroxy-1-H-pyrano[3′, 4′:6,7]indolizino-[1,2-b]quinoline-3,14(4H,12H)dione} from 10-hydroxy-camptothecin under solid-liquid phase transfer catalysis, which behaves both as a solvent and a reagent serving as for C-1 unit source for amino-alkylation of 10-hydroxy-(4S)-camptothecin.
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