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ALDH3B1 protein expression was induced in ARPE-19 cells by a
sublethal concentration of 4HNE. We have previously shown that
ALDH3B1 is up-regulated in various human tumors, which may be the
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In summary, kinetic and cytotoxicity studies reveal that ALDH3B1
efficiently metabolizes and protects cells from LPO-derived aldehydes
and oxidant compounds, indicating the enzyme has an important role
in the cellular defense against both oxidative stress and downstream
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Acknowledgments
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1
The authors thank Dr. David Thompson for critical reading and
discussion of this article. The work described in this report was
supported by NIH Grants EY11490 and EY17963 (V.V.) and NIH/
NIAAA Predoctoral Fellowship AA016875 (S.A.M.).
[
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