Tetrahedron Asymmetry p. 893 - 902 (1993)
Update date:2022-08-16
Topics:
Lu
Miet
Kunesch
Poisson
Both optically pure enantiomers of GABOB and isoserine were obtained by enzymatic kinetic resolution of acetylated precursors in three or four steps. The key intermediates were cyanohydrins available from simple aldehydes. This procedure can be applied to other unusual hydroxy amino acids widely distributed in biologically important peptides.
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