Nucleosides, nucleotides and nucleic acids p. 1795 - 1804 (2000)
Update date:2022-08-24
Topics:
Khandazhinskaya
Shirokova
Karpenko
Zakirova
Tarussova
Krayevsky
P-(Alkyl)esters of AZT 5′-hydrogenphosphonate were synthesized and their stabilities in the phosphate buffer and human serum were evaluated. The esters bearing residues of primary and secondary alcohols were degraded to give AZT, whereas those containing tertiary alkyl groups yielded AZT 5′-hydrogenphosphonate. The corresponding derivatives of d2A and d2T showed the same properties.
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