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3-[3-(2-Carboxy-ethylsulfanyl)-1,4-dioxo-1,4-dihydro-naphtha-
len-2-ylsulfanyl]-propionic acid 22
Method E. Stirring time = 48 h. Purification by flash chromato-
graphy (silica: EtOAc/MeOH, 19 : 1, 9 : 1, 4 : 1 and 2 : 1) to afford
a brown solid (0.0766 g, 69%). Rf = 0.15 (MeOH/EtOAc, 1 : 2).
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afford a brown solid (0.0669 g, 30%).
Method I. Stirring time = 48 h. Purification by preparative
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204 °C); TLC (MeOH/EtOAc, 1 : 10): Rf = 0.30. 1H NMR
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Acknowledgements
We thank the CSIR (Thematic A grant) for financial support,
Novozymes SA for a donation of the laccase (Novozymes
51003) and the NRF NEP funding program for the assistance in
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