Journal of Pharmacy and Pharmacology p. 42 - 47 (1988)
Update date:2022-08-16
Topics:
Karlberg
Bohlinder
Boman
Hacksell
Hermansson
Jacobsson
Nilsson
15-Hydroperoxyabietic acid (15-HPA) has been isolated from Portuguese colophony of the gum rosin type and identified as its methyl ester. The structure of the compound was elucidated using UV, IR, NMR and mass sepctrometry. 15-HPA methyl ester was found to be an elicitor when tested in colophony-sensitized guinea-pigs. The sensitizing capacity was verified in the same species and 15-HPA methyl ester was considered to be a strong allergen. The eliciting potential was also verified in patients with known allergy to colophony. The Portuguese gum rosin investigated contained approximately 1% of 15-HPA. Based on its allergenicity and the amounts isolated, we conclude that 15-HPA is a main contact allergen in Portuguese gum rosin.
View MoreSuZhou Ascepion Pharmaceuticals, Inc.
Contact:0512-86881668
Address:Building C,68Xingqing Road,Suzhou,China.
Ji'nan Orgachem Pharmaceutical Co.,Ltd
Contact:+86-531-82687810
Address:Jinan
Contact:+86-10-83993285
Address:Rm.1708, Haobai Tower, Building 6, No.50, North Road, West Third Ring, Haidian District, Beijing, China
Contact:+86-21-61318535
Address:Building 29,No.2139 Xizha Road, Fengxian District, Shanghai
Springchem New Material Technology Co.,Limited
website:http://www.spring-chem.com
Contact:86-21-62885108
Address:602B, Building 1, No. 641, Tianshan Road
Doi:10.1016/j.jallcom.2004.08.042
(2005)Doi:10.1080/00397919808005722
(1998)Doi:10.1021/acs.jnatprod.0c00830
(2021)Doi:10.1021/ol401055m
(2013)Doi:10.1016/S0009-2614(01)00803-X
(2001)Doi:10.1039/c6ra08855d
(2016)