Phosphorus, Sulfur and Silicon and the Related Elements p. 91 - 97 (2000)
Update date:2022-08-11
Topics:
Lu, Shui-Ming
Mao, Li-Juan
Xiong, Ye-Rong
A series of novel nitrogen mustard derivatives of 2, 4, 6-trioxo-1, 3, 5, 2-triazaphosphorine have been synthesized by the cyclization reactions of N, N-bis(2-chloroethyl)amino phosphonyl diisocyanate with amines. The structures of the products were confirmed by 1H NMR, IR, MS and elemental analysis. The preliminary bioassay indicated that some of the compounds significantly inhibited the growth of Leukemia L1210 cell in vitro.
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