Tetrahedron Asymmetry p. 2209 - 2213 (1997)
Update date:2022-08-11
Topics:
Braghiroli, Daniela
Avallone, Rossella
Di Bella, Maria
(R)- and (S)-2-Pyrrolidinemethanesulfonic acid, 3a and 3b, were synthesized from the corresponding N-Boc-2-(hydroxymethyl)-1-pyrrolidine, 6a and 6b. This asymmetric synthesis proceeds in mild conditions, with good overall yields and high enantiomeric purities (>99% ee).
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Doi:10.1021/ja903653j
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