Journal of Organic Chemistry p. 6001 - 6011 (2015)
Update date:2022-08-17
Topics:
Fitzgerald, Monica A
Soltani, Omid
Wei, Carolyn
Skliar, Dimitri
Zheng, Bin
Li, Jun
Albrecht, Jacob
Schmidt, Michael
Mahoney, Michelle
Fox, Richard J.
Tran, Kristy
Zhu, Keming
Eastgate, Martin D.
BMS-911543 is a complex pyrrolopyridine investigated as a potential treatment for myeloproliferative disorders. The development of a short and efficient synthesis of this molecule is described. During the course of our studies, a Ni-mediated C-N bond formation was invented, which enabled the rapid construction of the highly substituted 2-aminopyridine core. The synthesis of this complex, nitrogen-rich heterocycle was accomplished in only eight steps starting from readily available materials.
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